Oligonucleotide drug discovery
We provide a one-stop solution for complex oligonucleotide-base conjugated drugs, from discovery through development to commercial manufacturing.Supported by a wealth of experience, we offer flexible options with rapid turnaround time and comprehensive support for design and synthesis with analytical processes at any scale.
Types of molecules
- GalNAc-Oligonucleotide
- Peptide-Oligonucleotide
- Aptamer-Oligonucleotide
- Lipid-Oligonucleotide
- Toxin/Drug-Oligonucleotide
- Customized Small Molecule-Oligonucleotide
- …
Conjugation Chemistry
- Amide Coupling
- Thiol-maleimide Addition
- Click Chemistry: CuAAC | SPAAC
- Disulfide Chemistry
- Hydrazone Chemistry
Linkers & Ligands
- PS/CPG resin (GalNAc, lipid/PEG amine, biotine, dye etc.)
- Peptide conjugates (cell-penetrating peptide, cyclic peptide, Line peptide)
- Cleavable / uncleavable linkers with maleimide, DBCO, BCN, azide, VC-PAB etc.
Site of coupling
- 3′- or 5′-end conjugation
- Oligonucleotide moiety conjugates on base phosphorus backbones
- Complex dual conjugation: 3’,5’- | 3’,3’- | 5’,5’-
Positive oligo program experience, from end to end
Focusing on your needs and building long-term partnerships, your own Veliter’s project manager will be flexible and responsive. This is Veliter’s approach to make your oligonucleotide program move smoothly through pre-clinical to commercial.
Our Awards
